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cSVI-DM: a single-cell-guided, vascular-centered framework for layer-specific drug mapping in cerebral small vessel disease

Authors: Yuqian Li

Date: 2026-06-07 · Type: Method / Framework · Venue: Preprint

Abstract

cSVI-DM extends the cSVI framework from subtype definition to layer-specific drug mapping. It organizes cellular state scoring, cell-cell interaction scoring, ligand-receptor target mapping, and downstream compound prioritization into a vascular-centered translational workflow.

Keywords

cSVI-DMdrug mappingCSSCISLRSsingle-cellvascular-centered framework

Suggested citation

Yuqian Li. cSVI-DM: a single-cell-guided, vascular-centered framework for layer-specific drug mapping in cerebral small vessel disease. Preprint, 2026.

References

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